By Ava ThompsonMay 7, 2026 Sports Top 5 Biggest Winning Bets in U.S. Sports History: One Bettor Risked $3.46 Million Against Patrick Mahomes A bettor made headlines with a $3.46 million wager against NFL star Patrick Mahomes, marking one of the biggest wins in U.S. sports betting history, Yahoo Sports reports. This bet reshaped high-stakes wagering.